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The key event in activation of fluid secretion is an increase in [Ca 2+ ]i triggered by inositol 1,4,5-trisphosphate (IP3)-induced release of Ca 2+ from ER via the IP3 receptor (IP3R) and cells finely tune the generation and amplification of [Ca 2+ ]i signals for regulation of cell function [68]

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In women with obesity, excess adipose tissue often leads to increased peripheral conversion of androgens to oestrogens, creating a state of relative oestrogen excess